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左旋多巴是一种拟多巴胺类药物,临床主要用于治疗震颤麻痹。但近年来的研究发现,它还是一个可用于长期冶疗心力衰竭的有效药物。 Rajfer等曾用多巴胺静脉注射治疗心衰病人,出现明显的强心和排钠利尿作用。而多巴胺口服易在肠道和肝脏内破坏失效,故多巴胺必须静脉给药,从而使其对于心衰病人的长期治疗价值不大。多巴胺的前体药物左旋多巴可口服吸收,且在体内为芳香氨基酸脱羧酶催化转变成多巴胺,故近年来不少学者设想心衰病人口服左旋多巴将会产生与多巴胺类似的心血管效应,这一设想已为临床证实。
Levodopa is a pseudo-dopamine drugs, clinically used to treat paralysis paralysis. However, recent studies have found that it is also an effective drug that can be used to treat heart failure in the long term. Rajfer et al have used dopamine intravenous injection of heart failure patients, there was a significant cardiac and paralytic natriuretic effect. However, oral administration of dopamine is easy to destroy in the intestine and liver, so dopamine must be administered intravenously, which makes it less valuable for the long-term treatment of heart failure patients. In recent years, many scholars assume that oral administration of levodopa in patients with heart failure will produce similar cardiovascular effects as dopamine, and that dopamine, the precursor drug of levodopa, can be orally taken orally and is converted to dopamine catalyzed by aromatic amino acid decarboxylase in vivo. This idea has been clinically confirmed.