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1临床资料先证者女,73岁,颜面、躯干、四肢皮损20年,明显增大5年。患者20年前无明确诱因发现胸、背出现散在淡褐色斑,略高出皮肤表面,部分有黄豆大,呈灰褐色,易脱落,不出血,未予重视。次年因原有皮损体积逐渐增大,同时伴有类似新出皮疹,外院予以活检后确诊为“脂溢性角化症”。患者考虑良性肿物,仍保留皮损,未予特殊处理。10年后头面部、双腋下、前胸、后背处均有新出疣状皮损,体积较前增大、数量增多,颜色暗黑,需排除皮损恶性变的可能;遂予躯干部切取较典型组织行病理活检,报告示“脂溢性角化病”。患者因恐惧疼痛,拒绝冷冻治
1 clinical data proband female, 73 years old, face, trunk, limb lesions 20 years, significantly increased 5 years. Patient 20 years ago, there was no clear incentive to find the chest, back scattered scattered brown spots, slightly above the surface of the skin, some soybeans, gray-brown, easy to fall off, no bleeding, no attention. The following year due to the original volume of lesions gradually increased, accompanied by a new rash, the hospital was biopsy confirmed as “seborrheic keratosis ”. Patients considered benign tumor, still retain the skin lesions, no special treatment. 10 years after the head and face, double armpit, chest, back at the verge of verrucous lesions have increased compared to the previous volume increased, the number of dark colors, the possibility of malignant lesions to be ruled out; then cut to the trunk More typical histopathological biopsy, reported “seborrheic keratosis ”. Patients due to fear of pain, refused to cryotherapy