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目的观察大剂量米非司酮联合米索前列醇中期妊娠引产的临床效果。方法选取该院2012年6月-2014年6月收治的孕16~24周要求终止妊娠的患者200例,将所有患者随机分为观察组和对照组各100例。对照组给予常规剂量米非司酮联合米索前列醇终止妊娠。观察组给予大剂量米非司酮联合米索前列醇终止妊娠。观察2组流产情况,阴道出血时间及月经恢复时间。结果观察组的流产成功率为94%高于对照组的82%,阴道流血时间及月经恢复时间均短于对照组,差异均有统计学意义(P<0.05)。结论大剂量米非司酮联合米索前列醇口服能安全有效地终止16~24周妊娠,效果较好,可减少阴道出血量,且服药方法简便,具有临床推广价值。
Objective To observe the clinical effect of high dose mifepristone combined with misoprostol induction of labor in the second trimester of pregnancy. Methods A total of 200 patients requiring termination of pregnancy within 16-24 weeks of gestation from June 2012 to June 2014 in our hospital were selected and all patients were randomly divided into observation group and control group with 100 cases in each group. Control group given conventional dose of mifepristone combined with misoprostol termination of pregnancy. The observation group was given high-dose mifepristone combined with misoprostol to terminate the pregnancy. Two groups were observed abortion, vaginal bleeding time and menstruation recovery time. Results The success rate of abortion in the observation group was 94% higher than 82% in the control group, vaginal bleeding time and menstruation recovery time were shorter than the control group, the difference was statistically significant (P <0.05). Conclusion High-dose mifepristone combined with misoprostol can safely and effectively terminate the pregnancy of 16-24 weeks with good effect and reduce the amount of vaginal bleeding, and the method of taking medicine is simple and convenient, and has clinical value of popularization.