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麻醉猫6只,依次静脉注射盐酸木防己碱1.25,2.5,5.0,10.0,20.0mg/kg,血压下降30～60mmHg,血压下降的幅度与剂量有关。5mg/kg以上剂量均伴有呼吸短暂的抑制。 麻醉猫16只,分三组,分别用受体激动剂与拮抗剂等方法处理:第一组用硫酸阿托品、盐酸心得安、六甲双铵、切除双侧迷走神经。第二组用去甲肾上腺素。第三组用苯海拉明、西米替丁处理,分析对静脉注射盐酸木防己碱降压效应的机理。实验结果证实盐酸木防己碱的降压效应与胆碱能M受体、N受体、肾上腺素能β受体与α受体、迷走神经、H_1与H_2组胺受体以及神经节无关。因此,推测静脉注射盐酸木防己碱的降压效应可能主要与直接扩张血管平滑肌有关。
Cats were anesthetized 6, followed by intravenous injection of tetrandrine hydrochloride 1.25,2.5,5.0,10.0,20.0mg / kg, blood pressure decreased 30 ~ 60mmHg, the magnitude of the decline in blood pressure and dose. 5mg / kg above the dose is accompanied by short-term respiratory inhibition. Anesthetic cats 16, divided into three groups were treated with receptor agonists and antagonists and other methods: the first group with atropine sulfate, propranolol hydrochloride, hexamidine, bilateral vagus nerve excision. The second group used norepinephrine. The third group with diphenhydramine, cimetidine treatment, intravenous injection of tetrandrine hydrochloride antihypertensive effect mechanism. The experimental results confirm that the antihypertensive effect of tetrandrine hydrochloride has nothing to do with the cholinergic M receptor, N receptor, adrenergic beta receptors and alpha receptors, vagus nerve, H and H histamine receptors and ganglia. Therefore, it is speculated that intravenous infusion of tetrandrine hydrochloride antihypertensive effect may be mainly directly related to the expansion of vascular smooth muscle.