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Ca~(++)内流抑制剂有异搏定(verapamil,Ver),硝苯吡啶(nifedipine,Nif)和硫氮(艹卓)酮(diltiazem,Dil)是作用于心血管,具有广泛治疗作用的一类药物。像β-受体阻断剂,它具有抗心绞痛、抗高血压和抗心律失常等作用。因为它抑制钙道的Ca~(++)内流,故有钙离子拮抗剂,钙道阻断剂,慢道抑制剂等名称。一、药理作用 Ca~(++)是心肌细胞膜兴奋和肌球蛋白与肌动蛋白相互作用过程中介质,窦房结舒张期自动去极化是Ca~(++)内流所致,所以心率与Ca~(++)有依从性。Ca~(++)还具有维持动脉(包括冠脉在内)张力的作用。抑制Ca~(++)内流,则心肌的收缩力减弱,心肌的氧耗量减少,减慢窦性心率;抑制A-V传导,则心室率减慢,扩张动脉,血压下降等等。在作用部位上,
Verapamil (Ver), nifedipine (Nif) and diltiazem (Dil) are the most potent inhibitors of Ca ~ (++) influx in cardiovascular patients with extensive treatment A class of drugs. Like β-receptor blockers, it has anti-angina, antihypertensive and antiarrhythmic effects. Because it inhibits calcium Ca (++) influx, it has calcium antagonists, calcium channel blockers, slow channel inhibitors and other names. First, the pharmacological effects of Ca ~ (++) is the myocardial cell membrane excitability and myosin and actin interaction medium, the diastolic automatic sinoatrial depolarization is due to Ca ~ (++) influx, so Heart rate and Ca ~ (++) compliance. Ca ~ (++) also has the effect of maintaining the tension of the arteries, including the coronary arteries. Inhibition of Ca ~ (++) influx, myocardial contractility weakened myocardial oxygen consumption decreased, slowing sinus heart rate; inhibition of A-V conduction, the ventricular rate slowed, dilated arteries, blood pressure and so on. In the role of the site,