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本研究的目的是通过反复给镉而复制出的实验大鼠模型,详尽地评价肝脏防止镉引起微粒体膜的脂质过氧化作用而对血蛋白、细胞色素P-450的可能有害作用的自我保护能力。实验使用雄性Wistar大鼠,体重200～300g。实验组按0.1和0.5 mgCd/kg剂量作皮下注射,每周3次共5周;对照组注射等体积生理盐水。最后一次给镉后72小时,进行
The purpose of this study was to evaluate in detail the experimental rat model replicated with cadmium, a detailed assessment of the liver’s self-protection against the possible detrimental effects of cadmium on lipid peroxidation by microsomal membranes against hemoglobin, cytochrome P-450 Protection ability. The experiment used male Wistar rats weighing 200-300g. The experimental group was subcutaneously injected with 0.1 and 0.5 mgCd / kg dose for 3 weeks for 5 weeks. The control group was injected with equal volume of normal saline. 72 hours after the last cadmium, proceed