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目的 :制备盐酸伐昔洛韦分散片 ,并测定其溶出度。方法 :采用微晶纤维素、羧甲基淀粉钠、交联PVP等辅料制备分散片 ,制定溶出度测定方法 ,并对其进行质量评价和溶出度比较。结果 :用所筛选处方制备的分散片符合英国药典中有关分散片的要求 ,制剂质量可控 ,溶出度优于普通片。结论 :筛选的处方合理 ,制备的盐酸伐昔洛韦分散片比市售片崩解快、分散度均匀性好 ,溶出快而完全。
Objective: To prepare valacyclovir hydrochloride dispersible tablets and determine its dissolution. Methods: Dispersed tablets were prepared by using microcrystalline cellulose, sodium carboxymethyl starch and cross-linked PVP. The determination method of dissolution was established. The quality evaluation and dissolution were compared. Results: The dispersible tablets prepared by the selected prescriptions complied with the requirements of the British Pharmacopoeia for the dispersible tablets. The preparation quality was controlled and the dissolution rate was better than that of ordinary tablets. Conclusion: The prescription of screening is reasonable. The prepared valacyclovir dispersible tablets are faster than the commercial ones and have good uniformity of dispersion and quick and complete dissolution.