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目的:探讨CEA和PCNA在胃肠癌的表达情况,及其与临床病理特征之间的关系。方法:使用免疫组织化学的方法检测CEA和PCNA在胃肠癌石蜡切片的表达情况。结果:CEA在胃肠癌的表达率均在80%以上,CEA表达与结肠癌的淋巴结转移和Dukes分期有关;PCNA在胃肠癌均呈高表达,胃癌的肿瘤细胞表达率明显高于结肠癌,肿瘤侵袭前缘区域的肿瘤细胞高表达PCNA蛋白。结论:CEA和PCNA是胃肠癌较好的辅助诊断标记,对肿瘤的恶性程度评价有一定的意义。
Objective: To investigate the expression of CEA and PCNA in gastrointestinal cancer, and its relationship with clinicopathological features. Methods: Immunohistochemistry was used to detect the expression of CEA and PCNA in paraffin sections of gastrointestinal cancer. Results: The expression rate of CEA in gastrointestinal cancer was over 80%. CEA expression was related to lymph node metastasis and Dukes stage of colon cancer. PCNA was highly expressed in gastrointestinal cancer. The expression rate of gastric cancer was significantly higher than that of colon cancer. , Tumor cells in the tumor invasive frontal region express high levels of PCNA protein. Conclusion: CEA and PCNA are good auxiliary diagnostic markers for gastrointestinal cancer and have a certain significance for the evaluation of malignancy of tumors.