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目的分析探讨C-反应蛋白(CRP)水平与冠心病的相关性以及行经皮冠状动脉介入治疗(PCI)术后的变化意义。方法采用免疫浊度法测定71例冠心病PCI术患者(A组)及167例单行冠状动脉造影术者(B组)前后的血清CRP水平,并将B组分列为有冠脉狭窄组(B1组,118例)和无冠脉狭窄组(B2组,49例),比较3组患者血清CRP水平的变化。结果术前血清CRP水平冠心病患者(A组和B1组)明显高于无冠脉狭窄组(B2组)(P<0.01);冠心病PCI术患者(A组)术后血清CRP水平明显高于术前(P<0.05);单行冠状动脉造影术组(B组)血清CRP水平术后较术前差异无统计学意义(P>0.05)。结论CRP与冠心病发生密切相关;PCI能导致冠心病患者的内皮损伤,加重炎症反应,从而引起管腔再狭窄,因此PCI术后应加强抗炎治疗。
Objective To investigate the relationship between the level of C-reactive protein (CRP) and coronary heart disease and the significance of the changes after percutaneous coronary intervention (PCI). Methods Serum CRP level was measured by immunoturbidimetry in 71 patients with coronary artery disease (group A) and 167 patients with coronary artery angiography (group B), and group B was classified as coronary stenosis group B1 group, 118 cases) and no coronary artery stenosis group (B2 group, 49 cases). The changes of serum CRP level in three groups were compared. Results Preoperative serum CRP levels in patients with coronary heart disease (group A and group B1) were significantly higher than those without coronary artery stenosis (group B2) (P <0.01). Serum CRP levels were significantly higher in patients with coronary artery disease (group A) (P <0.05). There was no significant difference in serum CRP level between preoperative and postoperative coronary angiography (group B) (P> 0.05). Conclusions CRP is closely related to the occurrence of coronary heart disease. PCI can lead to endothelial injury in patients with coronary heart disease and aggravate inflammatory reaction, which leads to lumen restenosis. Therefore, anti-inflammatory treatment should be strengthened after PCI.