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目的探讨联合检测血清转铁蛋白(Tf)、癌胚抗原(CEA)对结直肠癌筛查的临床应用价值。方法对郑州市60个社区5000户社区居民(5000例)先行大便潜血联合免疫法初步筛查,阳性受试者采用全自动生化法及化学发光法进行血清转铁蛋白、癌胚抗原检测,两指标检测阳性者(超出参考值1.5倍)行结肠镜及镜下取组织行病理检查,明确有无结直肠癌病变并确定符合率。结果大便潜血筛查阳性率10.2%;而血清转铁蛋白增高占初筛受试者比例为10.0%,CEA升高则占初筛受试者比例为8.4%;两者均阳性与结肠镜诊断结直肠癌符合率为78.6%。结论通过大便潜血及联合血清转铁蛋白、癌胚抗原的检测,对临床结直肠癌筛查具有重要意义。
Objective To investigate the clinical value of combined detection of serum transferrin (Tf) and carcinoembryonic antigen (CEA) in the screening of colorectal cancer. Methods A total of 5000 community residents in 5000 communities in 60 communities in Zhengzhou were initially screened by fecal occult blood combined with immunoassay. The positive subjects were tested for serum transferrin and carcinoembryonic antigen using automatic biochemical and chemiluminescent methods. Indicators positive (1.5 times more than the reference value) line colonoscopy and microscopic examination of tissue taken line, clear the presence or absence of colorectal cancer and determine the compliance rate. Results The positive rate of fecal occult blood screening was 10.2%. The elevated serum transferrin accounted for 10.0% of primary screening subjects and CEA was 8.4% higher than primary screening subjects. Both were positive and colonoscopy The coincidence rate of colorectal cancer was 78.6%. Conclusions The detection of fecal occult blood combined with serum transferrin and carcinoembryonic antigen is of great significance for the screening of clinical colorectal cancer.