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目的:通过观察我院收治的结肠癌患者临床诊断资料,探讨分析血管内皮生长因子-C(VEGF-C)在该疾病患者中的生长以及淋巴转移的作用情况。方法:对我院收治的72例结肠癌患者与同期12例癌旁非癌组织患者,采用免疫组化法检测VEGF-C表达情况。结果:结肠癌与癌旁非癌组织患者的VEGF-C的阳性表达率分别为65.3%与8.3%,对比差异显著(P<0.05);VEGF-C在结肠癌中的表达与淋巴转移、浸润深度以及TNM分期情况有关(P<0.05)。结论:结肠癌患者血管内皮生长因子-C(VEGF-C)的阳性表达率高,具体表达的水平高低与患者的淋巴转移、结肠癌浸润深度以及TNM分期有关,值得临床上进一步探讨与研究。
Objective: To observe the clinical diagnosis of colon cancer patients admitted to our hospital to investigate the role of vascular endothelial growth factor-C (VEGF-C) in the growth of patients with the disease and lymphatic metastasis. Methods: The expression of VEGF-C in 72 patients with colon cancer and 12 patients with adjacent non-cancerous tissue in our hospital was detected by immunohistochemistry. Results: The positive rates of VEGF-C in colon cancer and adjacent non-cancerous tissues were 65.3% and 8.3%, respectively (P <0.05). The expression of VEGF-C in colon cancer was significantly correlated with lymphatic metastasis, Depth and TNM staging (P <0.05). Conclusion: The positive rate of vascular endothelial growth factor-C (VEGF-C) expression in colon cancer patients is high. The level of VEGF-C expression in patients with colon cancer is related to lymph node metastasis, depth of invasion of colon cancer and TNM staging. It is worth further exploration and research in clinic.