论文部分内容阅读
目的 :组织胞浆菌病是一种地方性真菌病。我国的自然条件适宜于组织胞浆菌生长与传播 ,但缺乏组织胞浆菌感染的流行病学资料。本研究目的是调查我国组织胞浆菌感染的流行情况。 方法 :30 0例正常人和 4 35例住院患者分别来源于湖南、江苏和新疆维吾尔自治区。前臂皮内注射酵母相组织胞浆菌素 (HIS ,美国ALK/Berke leyBiologicalsLaboratories生产 )和人型 结核菌素纯蛋白衍生物 (PPD) ,4 8～ 72h观察结果 ,最大红肿硬结直径≥ 5mm为阳性。 结果 :18.8% (138/ 735 )受试者HIS皮试阳性 ,阳性反应直径为 5 .0～ 4 5 .0 (9.1± 4 .3)mm。湖南、江苏和新疆三地正常人组HIS皮试阳性率有显著差异 ,分别为 8.9%、15 .1%和 2 .1% (P <0 .0 5 ,P <0 .0 1)。患者组HIS总阳性率为 2 5 .5 % ,明显高于相应地区正常人组 (P <0 .0 1)。肺结核患者阳性率为 31.7% (78/ 2 4 6 ) ,高于肺炎 17.7% (11/ 6 2 )、肺癌 2 0 .9% (9/ 4 3)、慢性阻塞性肺病 (COPD) 17.3% (9/ 5 2 )和其他疾病 12 .5 % (4 / 32 ) (P <0 .0 1)。PPD总阳性率为 5 2 .0 % (2 92 / 5 6 2 ) ,阳性反应直径为 5 .0～ 5 0 .0 (13.7± 4 .9)mm。两种抗原皮试均阳性者11.2 % ,均阴性者 4 2 .9% ,HIS皮试阳性而PPD阴性者 6 .8%。 结论 :我国存在组织胞浆?
Purpose: Histoplasmosis is a endemic mycosis. The natural conditions in our country are suitable for the growth and spread of histoplasma, but lack of epidemiological data of histoplasma infection. The purpose of this study was to investigate the prevalence of histoplasma infection in our country. Methods: 30 0 normal subjects and 355 inpatients were from Hunan, Jiangsu and Xinjiang Uygur Autonomous Region respectively. The forearm intradermal injection of yeast phase histoplasmin (HIS, the United States ALK / Berke ley Biologicals Laboratories production) and human tuberculin pure protein derivative (PPD), 48 ~ 72h observations, the largest inflamed induration diameter ≥ 5mm positive . Results: HIS skin test was positive in 18.8% (138/735) subjects, and the positive reaction diameter was 5.0-0.45.0 (9.1 ± 4.3) mm. The positive rates of HIS skin test in normal subjects in Hunan, Jiangsu and Xinjiang were significantly different (8.9%, 15.1% and 2.1%, P <0.05, P <0.01). The positive rate of HIS in patients was 25.5%, which was significantly higher than that in normal subjects (P <0.01). The positive rate of tuberculosis was 31.7% (78/246), higher than that of pneumonia (17.6%), lung cancer (20.4%), chronic obstructive pulmonary disease (COPD) 9/5 2) and other diseases 12.5% (4/32) (P <0.01). The positive rate of PPD was 52.0% (92/56) and the positive reaction diameter was 5.0-0.50.0 (13.7 ± 4.9) mm. The two antigens skin test were positive 11.2%, 42.2% were negative, HIS skin test positive and PPD negative were 6.8%. Conclusion: There is tissue cytoplasm in our country?