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1资料与方法1.1一般资料我科室从2008年以来收治的急性重度有机磷中毒患者36例,男11例,女25例,年龄范围在20～78岁之间,均为口服中毒,口服量30～250ml。经过积极抢救治疗,治愈33例,死亡3例。常见口服中毒有机磷杀虫剂包括乐果,敌敌畏,马拉硫磷及混合有机磷杀虫剂。诊断:根据服药病史,临床症状,全血胆碱酯酶(ChE)活性均诊断为重度中毒[1]。1.2方法1.2.1一般方法初步诊断后,立即清除口鼻腔分泌物,清洁皮肤头发有毒污物,立即彻底洗胃,导泻,灌肠。洗胃是采用负压吸引器借助手工反复洗胃,每4h洗胃一次。导泻用25%甘露醇液250ml洗胃后经胃管注入,根据患者排便情况
1 Materials and Methods 1.1 General Information Our department since 2008, admitted to the acute severe organic phosphorus poisoning in 36 patients, 11 males and 25 females, aged between 20 to 78 years old, are oral poisoning, oral dose of 30 ~ 250ml. After active rescue treatment, 33 cases were cured and 3 died. Common oral poisoning Organophosphate pesticides include dimethoate, dichlorvos, malathion and mixed organophosphate insecticides. Diagnosis: According to medication history, clinical symptoms, blood cholinesterase (ChE) activity were diagnosed as severe poisoning [1]. 1.2 Methods 1.2.1 General Methods After the initial diagnosis, immediately clear the mouth and nose secretions, clean the skin of toxic hair contaminated immediately gastric lavage, catharsis, enema. Gastric lavage is the use of negative pressure suction device manually repeated gastric lavage, gastric lavage once every 4h. Catharsis with 25% mannitol 250ml after gastric lavage gastric lavage, according to the patient defecation