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目的:观察在儿童乙肝疫苗接种中年龄对抗体阳转率的影响。方法:本研究的研究对象为我中心在2015年1月至2016年1月期间接种的乙肝疫苗儿童150例,对其接种效果进行观察。结果:经过观察发现,高免疫应答79例,所占比例为52.67%,低免疫应答56例,所占比例为37.33%,无免疫应答15例,所占比例为10.00%,总免疫应答率为90.00%;与5-8岁儿童相比,3岁以下儿童总免疫应答率及高免疫应答率明显较高,差异对比P<0.05,可见年龄越大免疫应答率越低,抗体阳转率越低。结论:在儿童乙肝疫苗接种中年龄对抗体阳转率具有一定的影响,年龄越小免疫应答越高,年龄越大免疫应答越低,因此乙肝疫苗接种要尽早。
Objective: To observe the effect of age on antibody positive rate in childhood hepatitis B vaccination. Methods: The study was conducted in 150 children with hepatitis B vaccine who were vaccinated by our center from January 2015 to January 2016, and the effect of inoculation was observed. Results: The results showed that there were 79 cases with high immune response, accounting for 52.67%, 56 cases with low immune response, accounting for 37.33%, 15 cases without immune response, accounting for 10.00%, and the total immune response rate was 90.00%. Compared with children aged 5-8 years, the total immune response rate and high immune response rate of children under 3 years old were significantly higher than that of children aged 5-8, P <0.05, the higher the age, the lower the immune response rate, low. Conclusion: Age in children with hepatitis B vaccination has a certain impact on the rate of antibody positive conversion. The younger the age, the higher the immune response, the older the lower the immune response, so hepatitis B vaccination as soon as possible.