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目的 比较电化学疗法与射频治疗对大鼠种植型肝癌的治疗效果。方法 制作大鼠肝癌动物模型 ,分别应用电化学疗法与射频疗法进行治疗 ,1周后影像学、病理光镜观察肿瘤大小、坏死、凋亡变化 ,与荷瘤对照组比较 ,并观察生存期的长短。结果 治疗前 ,所有大鼠肝肿瘤平均体积为 (10 0±6 )mm3 ,治疗后 1周 ,电化学治疗组大鼠肝肿瘤平均体积为 (12 5± 10 )mm3 ,射频治疗组大鼠肝肿瘤平均体积为 (14 3± 12 )mm3 ,而荷瘤对照组肝肿瘤平均体积为 (190± 11)mm3 ;两治疗组间比较差异无显著性 ,与对照组比较差异有显著性P <0 .0 5。两治疗组组织病理检查 ,光镜下均见肿瘤组织坏死明显 ,并可诱发细胞凋亡 ;生存期明显延长。结论 电化学疗法与射频治疗均可明显促进肿瘤坏死 ,诱发细胞凋亡 ,抑制肿瘤生长 ,延长大鼠生存期
Objective To compare the therapeutic effects of electrochemotherapy and radiofrequency ablation on implanted hepatocellular carcinoma in rats. Methods Animal models of rat liver cancer were made and treated with electrochemotherapy and radiofrequency ablation respectively. One week later, the changes of tumor size, necrosis and apoptosis were observed by light microscopy and pathological light microscope. The survival time length. Results Before treatment, the average volume of liver tumors in all rats was (10 ± 6) mm3. After 1 week of treatment, the average volume of liver tumors in the electrochemical treatment group was (125 ± 10) mm3. The mean volume of tumor was (14 3 ± 12) mm 3, while the average volume of liver tumor in tumor-bearing control group was (190 ± 11) mm 3. There was no significant difference between the two treatment groups, the difference was significant compared with the control group .0 5. Histopathological examination of both treatment groups, under the light microscope showed tumor necrosis was obvious, and can induce apoptosis; survival was significantly longer. Conclusion Electrochemotherapy and radiofrequency ablation can significantly promote tumor necrosis, induce apoptosis, inhibit tumor growth and prolong survival of rats