C-di-GMP signaling and implications for pathogenesis of Mycobacterium tuberculosis

• 出 处: Chinese Science Bulletin
• 发表日期: 2012年34期
• 关键词: tuberculosis signaling Mycobacterium biofilm downstream pathogenesis eukaryotic

C-di-GMP is a ubiquitous bacterial second messenger that regulates a wide range of bacterial physiological processes including biofilm formation, virulence, motility and cell differentiation. Here, we have summarized our current knowledge on the upstream signaling factors and downstream effectors of c-di-GMP in addition to the interaction between c-di-GMP and eukaryotic organisms. New discoveries in these areas have enriched our understanding of the diversity of c-di-GMP signaling pathways and provide important clues for us to explore the roles of c-di-GMP signaling in human pathogens such as Mycobacterium tuberculosis.

Here, we have summarized our current knowledge on the upstream signaling factors and downstream effectors of c- di-GMP in addition to the interaction between c-di-GMP and eukaryotic organisms. New discoveries in these areas have enriched our understanding of the diversity of c-di-GMP signaling pathways and provide important clues for us to explore the roles of c -di-GMP signaling in human pathogens such as Mycobacterium tuberculosis.