Inhibitory Effects of High Glucose/Insulin Environment on Osteoclast Formation and Resorption in vit

• 作 者: 徐飞 叶亚平 董永辉 郭风劲 陈安民 黄仕龙
• 机 构: DepartmentofOrthopedics
• 出 处: Journal of Huazhong University of Science and Technology(Med
• 发表日期: 2013年2期
• 关键词: 破骨细胞 胰岛素 葡萄糖 抑制作用 环境 2型糖尿病 体外 TRAP osteoclastogenesis glucose insulin type 2

Patients with type 2 diabetes mellitus (T2DM) exhibit hyperglycemia and hyperinsulinemia and increased risk of fracture at early stage, but they were found to have normal or even enhanced bone mineral density (BMD). This study was aimed to examine the mol