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目的:研究高危型人乳头瘤病毒(HR-HPV)对非典型鳞状细胞(ASC)或低度鳞状上皮内病变(LSIL)患者进行宫颈环形电切(LEEP)治疗的辅助诊断价值。方法:回顾性分析186例ASC或LSIL患者的HR-HPV检测、阴道镜下活检病理和LEEP病理结果,比较HR-HPV阳性和阴性患者中高级别病变(CIN2+)的发生率。结果:ASCUS、ASC-H和SLIL患者中HR-HPV的阳性率分别为67.1%、75.0%和89.3%,活检病理结果为CIN2+的比例分别为13.4%、60.0%和32.1%,而LEEP病理结果为CIN2+的比例分别为19.5%4、5.0%和33.3%。最终病理结果为CIN2+的患者在HR-HPV阳性患者中的比例为37.9%,而在HR-HPV阴性患者中的比例为17.0%,差异具有显著性(χ2=5.873,P=0.015)。结论:细胞学结果为低级别病变的患者中存在较高比例的高级别病变患者,检测HR-HPV有助于及时发现高级别病变患者。
Objective: To investigate the diagnostic value of high-risk human papilloma virus (HR-HPV) in the treatment of atypical squamous cell (ASC) or low-grade squamous intraepithelial lesion (LSIL) Methods: The HR-HPV test, colposcopic biopsy and LEEP pathology were retrospectively analyzed in 186 patients with ASC or LSIL. The incidence of high-grade lesions (CIN2 +) in HR-HPV positive and negative patients was compared. Results: The positive rates of HR-HPV in ASCUS, ASC-H and SLIL were 67.1%, 75.0% and 89.3%, respectively. The pathological results of CIN2 + were 13.4%, 60.0% and 32.1% The proportions of CIN2 + were 19.5%, 4.5.0% and 33.3%, respectively. The proportion of patients with a final pathological result of CIN2 + was 37.9% in HR-HPV positive patients and 17.0% in HR-HPV negative patients (χ2 = 5.873, P = 0.015). CONCLUSIONS: There is a high proportion of high-grade lesions in patients with low-grade disease cytology, detection of HR-HPV helps to detect patients with high-grade lesions in a timely manner.