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目的观察应用静脉注射丙种球蛋白辅助治疗极低体重儿肺炎的疗效。方法两组病儿均采用同样严格的常规综合治疗。治疗组在常规治疗的基础上加用丙种球蛋白静脉滴注,连用3 d,用药前和第3次用药后5 d采血查免疫球蛋白IgG、IgA、IgM。结果治疗组总有效率71.4%,对照组总有效率40.5%。两组比较,差异具有统计学意义(χ2=6.95,P<0.01),并且治疗组退热时间、停氧时间、肺部啰音消失时间及住院时间均较对照组明显缩短。两组治疗前血清中IgG水平差异无统计学意义。治疗组3次静脉注射丙种球蛋白后IgG水平显著高于治疗前,治疗后5 d升高明显(t=14.808,P<0.01),而对照组IgG水平则无明显提高,两组比较差异有统计学意义。而IgA和IgM于丙种球蛋白治疗前后无明显变化。结论静脉注射丙种球蛋白辅助治疗低出生体重儿肺炎十分有效。
Objective To observe the curative effect of intravenous administration of gamma globulin in the treatment of children with very low birth weight pneumonia. Methods Two groups of sick children were treated with the same rigorous conventional treatment. On the basis of routine treatment, the treatment group received intravenous infusion of gamma globulin for 3 days, and the immunoglobulin IgG, IgA and IgM were collected by blood sampling 5 days before and after the third administration. Results The total effective rate was 71.4% in the treatment group and 40.5% in the control group. The difference between the two groups was statistically significant (χ2 = 6.95, P <0.01), and the treatment group, antipyretic time, oxygen time, disappearance of pulmonary rales and hospital stay were significantly shorter than the control group. There was no significant difference in IgG level between the two groups before treatment. The level of IgG in the treatment group was significantly higher than that before treatment after 3 intravenous gamma globulin treatment (P <0.01), but the IgG level in the control group was not significantly increased Statistical significance. The IgA and IgM in the gamma globulin before and after treatment no significant change. Conclusion Intravenous gamma globulin is very effective in adjuvant treatment of low birth weight pneumonia.