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目的探讨卵巢子宫内膜异位囊肿对体外受精-胚胎移植(IVF-ET)的影响。方法对2002年1月至2006年12月在广州医学院第三附属医院行IVF-ET的120例(148周期)卵巢子宫内膜异位囊肿患者作回顾性分析。120例分别在降调节日和控制性超促排卵(COH)启动日行经阴道超声引导下卵巢子宫内膜异位囊肿穿刺术,将取卵日仍有卵巢子宫内膜异位囊肿患者46例(55周期)作为观察组,取卵日无卵巢子宫内膜异位囊肿患者74例(93周期)作为对照组。比较两组IVF-ET的结局。结果两组人绒毛膜促性腺激素(HCG)日雌二醇(E2)水平、移植胚胎数相似;观察组受精率[(61.5±23.6)%]、妊娠率(34.5%)稍低于对照组[(69.2±25.0)%,36.6%],但差异无显著性意义(P>0.05);观察组获卵数[(8.3±5.2)个]、优质胚胎数[(4.9±3.8)个]明显低于对照组[(10.5±7.6)个,(7.2±4.3)个](P<0.05);促性腺激素(Gn)总量明显高于对照组(P<0.05),取卵时间明显长于对照组(P<0.05)。结论卵巢子宫内膜异位囊肿对IVF-ET有一定的不良影响,导致Gn用量增加,取卵时间延长,获卵数和优质胚胎数减少。
Objective To investigate the effect of ovarian endometriosis on in vitro fertilization-embryo transfer (IVF-ET). Methods A retrospective analysis was performed on 120 cases (148 cycles) of ovarian endometriosis patients who underwent IVF-ET at the Third Affiliated Hospital of Guangzhou Medical College from January 2002 to December 2006. 120 cases of ovarian endometriosis cyst puncture under the guidance of vaginal ultrasound on the day of down regulation and the control day of ovulation induction (COH), respectively. There were 46 patients with ovarian endometriosis 55 cycles) as the observation group, ovulation ovarian endometriosis cyst in 74 patients (93 cycles) as a control group. The outcomes of IVF-ET in both groups were compared. Results The level of estradiol (E2) and the number of transferred embryos in HCG group were similar in both groups. The fertilization rate in the observation group [(61.5 ± 23.6)%] and pregnancy rate (34.5%) were slightly lower than those in the control group [(69.2 ± 25.0)%, 36.6%], but the difference was not significant (P> 0.05). The number of oocytes in the observation group [(8.3 ± 5.2)] and the number of high quality embryos [(4.9 ± 3.8) (10.5 +/- 7.6), (7.2 +/- 4.3)] (P <0.05). The total amount of gonadotropin (Gn) in the control group was significantly higher than that in the control group (P <0.05) Group (P <0.05). Conclusion Ovarian endometriosis cyst has certain adverse effects on IVF-ET, resulting in increased Gn dosage, prolonged oocyte retrieval, fewer oocytes and lower quality embryos.