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咳必定,化学名称为2-甲基-2-苯氧基-2-(4-吗啉)-丙酸乙酯盐酸盐。 文献报道咳必定(国外商品名Morphethylbutyne,α-苯氧基异丁酸的β-吗啉乙酯盐酸盐)在动物试验中显示具有与可待因(Codeine)相类似的镇咳作用,无可待因那样的不良付作用,毒性小,熔点为143～145℃。临床试用(27个病例)证明咳必定具有与可待因相同的镇咳效果。
Cough must, under the chemical name 2-methyl-2-phenoxy-2- (4-morpholine) -propionate hydrochloride. It has been reported in the literature that coumadin (the foreign trade name of Morphethylbutyne, β-morpholine ethyl ester hydrochloride of α-phenoxyisobutyric acid) showed antitussive action similar to Codeine in animal experiments, Codeine that adverse effects, toxicity, melting point of 143 ~ 145 ℃. Clinical trials (27 cases) demonstrate that cough must have the same antitussive effect as codeine.