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目的:了解宜昌地区妇科门诊就诊人群宫颈人乳头状瘤病毒(human papil-lomavirus,HPV)感染率以及基因亚型的分布特征。方法:采用核酸分子快速导流杂交基因芯片技术(flow-through hybridisation and geno-typing technique,Hybri-Max)对1 038例妇科门诊就诊患者的宫颈刷片标本进行了21种HPV基因分型检测分析。结果:1 038例妇女中检测出HPV阳性患者共153例,总阳性率为14.74%,其中HPV单一感染128例,占阳性患者的83.66%,二重混合感染13.07%,三重混合感染3.27%,人群中感染前5位的高危型依次是HPV16(3.3.28%)、HPV52(2.12%)、HPV58(1.93%)、HPV53(1.64%)和HPV31(1.35%)。最常见的低危型是HPV11(1.25%)。结论:该地区受检妇女HPV的检出率较高,且以高危型HPV感染为主,感染型别既符合亚洲及中国地区人群的分布规律,又有一定的区域差异。
Objective: To investigate the prevalence of cervical papillomavirus (HPV) infection and the distribution of genotypes in gynecological clinic in Yichang. METHODS: Twenty-one HPV genotyping tests were performed on 1,008 gynecological outpatient gynecological cervical swab specimens using flow-through hybridisation and geno-typing technique (Hybri-Max) . Results: A total of 153 HPV positive cases were detected in 1 038 women with a total positive rate of 14.74%. Among them, 128 were single HPV infection, accounting for 83.66% of patients with positive HPV, 13.07% of double infection, 3.27% of triple infection, The top 5 high risk groups in the population were HPV16 (3.3.28%), HPV52 (2.12%), HPV58 (1.93%), HPV53 (1.64%) and HPV31 (1.35%). The most common low-risk type is HPV11 (1.25%). Conclusion: The detection rate of HPV in the tested women in this area is high, and high-risk type HPV infection is the main type. The infection type accords with the distribution rules of the population in Asia and China with a certain regional difference.