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目的探讨颅内生殖细胞瘤的综合治疗方法。方法临床诊断颅内生殖细胞瘤13例，其中孤立型8例，侵袭型4例，播散型1例；治疗上对孤立型采取局灶放疗同时联合顺铂、足叶乙甙化疗，侵袭型与播散型加用氨甲喋呤脑室或鞘注给药化疗。结果肿瘤完全消失11例，瘤体缩小90％以上2例，随访0.3～4．5年（平均2．7年），无1例复发，全部病例生存状况良好。结论治疗上针对肿瘤的临床分型，采取局灶放疗与不同的化疗方案联合能有效的控制肿瘤，减少毒副作用，是颅内生殖细胞瘤的有效治疗方法。
Objective To investigate the comprehensive treatment of intracranial germinoma. Methods Thirteen cases of intracranial germinoma were diagnosed clinically, of which 8 were isolated, 4 were invasive and 1 were disseminated. The treatment of isolated solitary and local radiotherapy combined with cisplatin, etoposide, And disseminated plus methotrexate ventricular or sheath injection chemotherapy. Results The tumor completely disappeared in 11 cases, the tumor was reduced by 90% in 2 cases, followed up for 0.3-3.5 years (mean 2.7 years). No recurrence was found. All cases were in good condition. Conclusion The clinical treatment of tumor type, the combination of local radiotherapy and chemotherapy regimen can effectively control the tumor and reduce side effects, is an effective treatment of intracranial germinoma.