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用济南假单胞菌苗胸膜腔内注射治疗恶性胸膜腔积液进行前瞻性Ⅱ期临床研究。病人共126例,其中肺癌合并胸膜腔积液者96例,乳腺癌13例,恶性淋巴瘤8例,其它肿瘤9例。2～8ml/次,1次/周。结果表明:总有效率为80.2%。其中肺癌合并胸水者的疗效为83.3%(80/96)、乳腺癌76.9%(10/13)、恶性淋巴瘤75%(6/8)、其它肿瘤55.5%(5/9)。其中有15例既往胸膜腔内曾注射丝裂霉素或顺铂无效,改用 PJV后其中8例有效。本品的主要副作用有发热和局部疼痛,少数病人有恶心、呕吐。
A prospective phase II clinical study of malignant pleural effusions was performed using Pseudomonas syringae pv. A total of 126 patients were involved, including 96 patients with lung cancer and pleural effusion, 13 with breast cancer, 8 with malignant lymphoma, and 9 with other tumors. 2~8ml/time, once/week. The results show that the total effective rate is 80.2%. The efficacy of lung cancer with pleural effusion was 83.3% (80/96), breast cancer 76.9% (10/13), malignant lymphoma 75% (6/8), and other tumors 55.5% (5/9). Of these, 15 cases had previously had mitomycin C or cisplatin ineffective in the pleural cavity, and 8 of them were effective after PJV. The main side effects of this product are fever and local pain. A few patients have nausea and vomiting.