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高级脂肪酸甘油三酯(TG)仅在小肠中被胆汁和胰脂酶分解,如用它包裹药物,则在胃中不释药,达十二指肠后才释放药物,因此可制备肠溶制剂。本文用月桂酸甘油三酯(TL)、肉豆蔻酸甘油三酯(TM)、棕榈酸甘油三酯(TP)和硬脂酸甘油三酯(TS),分别包裹磺胺甲基异(口恶)唑(SMZ)制成TG小球和双层小球(DCTS),研究其肠溶特性。 TG小球的制法是取TG 18 g,于50～76℃熔融后,加SMZ2g混悬,在搅拌下倒入1%明胶液200 ml(40～65℃)中,使乳化,再在搅拌下倾入200 ml(0℃)水中,滤取
Higher fatty acid triglyceride (TG) is only in the small intestine bile and pancreatic lipase decomposition, such as using it to wrap the drug, the release of the drug in the stomach, after the duodenum to release the drug, it can be prepared enteric-coated formulations . In this paper, laurate triglyceride (TL), myristic acid triglyceride (TM), palmitic acid triglyceride (TP) and stearic acid triglyceride (TS) Pyrazole (SMZ) was made into TG pellets and double-layer globules (DCTS) to study their enteric properties. TG ball preparation method is to take TG 18 g, melted at 50 ~ 76 ℃, add SMZ2g suspension, stirring into 1% gelatin solution 200 ml (40 ~ 65 ℃), the emulsion, and then stirred Pour into 200 ml (0 ° C) water and filter