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作者对Ca 拮抗药是否抑制吸烟的急性效应进行了研究。对象与方法:经常吸烟男子35名为对象,分3组,Ⅰ组为健康者20名(平均年龄50.4岁,平均每天吸烟22.8支,吸烟28.3年),Ⅱ组为应用Ca 拮抗药心痛定(平均每天用量38.2mg,平均使用18.4个月)的特发性高血压患者11名(平均年龄61.5岁,平均每天吸烟18支,37.4年),Ⅲ组为未使用降压药的特发性高血压患者4名(平均年龄52.6岁,平均每天吸烟19.2支,31.6年)。被试者采取卧位。过滤嘴烟每支含尼古丁2mg,每5min 吸1支,每支吸2/3,连续吸2支,记录吸烟前及吸烟开始5,10,30min 后的血压、心率、心排出量,同时采血。检查开始1.5小时前投给心痛定10mg(?)服长效剂的9例于2小时
The authors studied whether Ca antagonists suppress the acute effects of smoking. PARTICIPANTS AND METHODS: Thirty-five men who were regularly smokers were enrolled in three groups. Group I consisted of 20 healthy individuals (average age 50.4 years, with an average of 22.8 cigarettes per day and 28.3 years of smoking) Average daily dose of 38.2mg, an average of 18.4 months) of idiopathic hypertension in 11 patients (mean age 61.5 years, an average of 18 cigarettes per day, 37.4 years), the group of non-use of antihypertensive drugs idiopathic high 4 patients with blood pressure (average age 52.6 years, with an average of 19.2 cigarettes per day, 31.6 years). The subjects took the supine position. Filter cigarettes each containing 2mg nicotine, every 5min suck 1, each suck 2/3, continuous suck 2, record before smoking and smoking 5,10,30 min after the start of blood pressure, heart rate, cardiac output, while blood. 1.5 hours before the start of the test cast heartache given 10mg (?) Long-acting agent in 9 cases in 2 hours