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近年来就基因治疗 1型糖尿病进行了广泛的实验性研究 ,其研究热点主要集中在下列三方面 :①诱导胰岛 β细胞特异性T淋巴细胞的耐受 ,以阻止 β细胞的自身免疫性破坏 ;②体外构建具有生理调节性胰岛素分泌的功能细胞 ,以供体内移植 ;③逆转代谢紊乱 ,防止并发症的发生。
In recent years, a wide range of experimental studies on gene therapy of type 1 diabetes have been conducted. The research focuses mainly on the following three aspects: ①tolerance of pancreatic β-cell-specific T lymphocytes to prevent the β-cell autoimmune destruction; ② in vitro construction with physiological regulatory insulin secretion of functional cells for transplantation in vivo; ③ reversal of metabolic disorders, to prevent the occurrence of complications.