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目的对接受维持性血液透析的终末期肾病患者的龋病和牙周健康状况进行系统评价。方法计算机检索中国学术期刊全文数据库(CNKI)、万方数据库、Pub Med、Web of Science、Cochrane Library数据库,收集国内外公开发表的研究血液透析患者口腔健康状况的病例对照和横断面研究,检索时间截止2016年5月。由2名研究者根据纳入与排除标准对相关文献进行筛选,并对文献进行质量评价和提取数据,对同质研究采用Revman 5.3软件进行Meta分析。结果研究最终纳入16篇文献,Meta分析结果显示,血液透析患者人群的牙菌斑指数(MD=0.62,95%CI为0.51~0.72)、牙石指数(MD=1.09,95%CI为0.56~1.63)、牙周袋深度(MD=0.63,95%CI为0.29~0.98)、附着丧失(MD=0.63,95%CI为0.56~0.69)均高于对照组(P<0.01),而龋失补牙数(MD=1.12,95%CI为-1.08~3.32)与对照组无统计学差异(P=0.32)。结论行血液透析治疗的终末期肾病患者的龋病状况与健康对照人群无明显差异,但口腔卫生和牙周状况较差,在临床治疗时需得到重视。
Objective To systematically evaluate the caries status and periodontal health of end-stage renal disease patients undergoing maintenance hemodialysis. Methods The databases of CNKI, Wanfang Database, PubMed, Web of Science and Cochrane Library were searched by computer. The case-control and cross-sectional studies published at home and abroad were collected to study the oral health status of hemodialysis patients. As of May 2016. Two researchers screened the relevant literature according to inclusion and exclusion criteria, and evaluated the quality of the literature and extracted the data. Meta-analysis was performed on the homogeneous study using Revman 5.3 software. RESULTS: Sixteen articles were finally included in the study. Meta-analysis showed that the plaque index (MD = 0.62, 95% CI 0.51-0.72), tartar index (MD 1.09, 95% CI 0.56-1.63 ), The depth of periodontal pocket (MD = 0.63, 95% CI 0.29-0.98), the loss of attachment (MD 0.63, 95% CI 0.56-0.69) were higher than those of the control group (P <0.01) (MD = 1.12, 95% CI -1.08 ~ 3.32) was not significantly different from the control group (P = 0.32). Conclusions The dental caries status of patients with end stage renal disease treated with hemodialysis is not significantly different from that of healthy control subjects, but oral health and periodontal status are poor, which should be paid more attention in clinical treatment.