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目前,通过肿瘤直接标记物对结直肠癌进行首次诊断和术后监测仍不能令人满意。一些结直肠癌标记物如CEA、组织纤维蛋白激酶(TPA)、CA50、CA19-9、CA72-4等其诊断价值及预后意义较差。作者通过对36例结直肠癌患者及162例正常对照组测定总IgG、IgG_1及IgG_2,发现IgG_1对结直肠癌首次诊断及术后监测具有重要意义。 36例患者术前或行结肠镜检查前采用亲合色谱法测定总IgG、IgG_1、IgG_2。所有患者的首次诊断均以组织学诊断为依据,其中5例为良性息肉恶变的早期结直肠癌患者,该组病人的肿瘤分期采用改良Dukes分期,162名健康者作为对照组也采用同样方法测IgG及亚
At present, the first diagnosis and postoperative monitoring of colorectal cancer by direct tumor markers are still unsatisfactory. Some colorectal cancer markers such as CEA, tissue fibrin kinase (TPA), CA50, CA19-9, and CA72-4 are of poor diagnostic value and prognostic significance. The authors measured total IgG, IgG_1, and IgG_2 in 36 patients with colorectal cancer and 162 normal controls and found that IgG_1 was of great significance for the first diagnosis and postoperative monitoring of colorectal cancer. Thirty-six patients were tested for total IgG, IgG_1, and IgG_2 by affinity chromatography before or before colonoscopy. The first diagnosis of all patients was based on histological diagnosis. Among them, 5 cases were early stage colorectal cancer patients with benign polyps. The tumor staging of patients in this group was improved by Dukes stage, and 162 healthy persons were also used as control group by the same method. IgG and Asian