Optimal concentration of necrostatin-1 for protecting against hippocampal neuronal damage in mice wi

• 作 者: Dong-Qi Lin Xin-Ying Cai Chun-
• 机 构: DepartmentofCardiothoracicSurgery,DepartmentofNeurosurgery,ClinicalResearchCenter
• 出 处: 中国神经再生研究:英文版
• 发表日期: 2020年5期
• 关键词: apoptosis Bax Bcl-2 cleaved-Caspase-3 EPILEPSY HIPPOCAMPAL NEURON MLKL NECROPTOS
• 基金项目: supported by the Key Discipline Construction Project of the Union Hospital of Fujian Province,China,No.Δ211002#.

Hippocampal neurons undergo various forms of cell death after status epilepticus.Necrostatin-1 specifically inhibits necroptosis mediated by receptor interacting protein kinase 1 (RIP1) and RIP3 receptors.However,there are no reports of necroptosis in mou