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目的 研究 40岁以下患者舌鳞状细胞癌的组织病理学特征。方法 采用常规组织学、免疫组织化学方法对 45例 40岁以下舌癌患者的癌组织进行研究 ,以 70岁以上舌癌患者的癌组织作为对照。结果 年轻患者的舌癌以Ⅱ级鳞癌为主 ,而老年组患者以Ⅰ级鳞癌为主 ,两者组织学分级的构成差异有显著性 (P <0 0 5 ) ;年轻患者肿瘤的侵袭缘多呈细条索状 ,而老年患者多为较大的团块 ;年轻组患者区域淋巴结转移阳性率 (37 5 % )显著高于老年组患者 (15 4% ) ;年轻组p5 3呈强阳性表达者显著高于老年组 ,CK13强阳性表达者显著低于老年组 (P分别 <0 0 5 )。结论 40岁以下患者舌鳞状细胞癌的恶性程度在总体上可能高于老年患者
Objective To investigate the histopathological features of tongue squamous cell carcinoma in patients under 40 years of age. Methods Conventional histological and immunohistochemical methods were used to study the cancer tissues of 45 cases of tongue cancer patients under 40 years of age. Cancer tissues of tongue cancer patients over 70 years old were used as controls. Results The grade 2 grade squamous cell carcinoma was the predominant tongue cancer in young patients, while the grade 1 grade squamous cell carcinoma was the predominant type in elderly patients. The histological grading of the two groups was significantly different (P < 0.05); The margins are mostly thin cords, and older patients are mostly larger masses; the positive rate of lymph node metastasis in the young group (37.5%) is significantly higher than that in the elderly group (15.4%); the young group is strongly positive in the p53. The expression of CK13 was significantly lower than that of the elderly group (P<0.05 respectively). Conclusion The malignant degree of tongue squamous cell carcinoma in patients under 40 years old may be higher than that of elderly patients in general