论文部分内容阅读
目的观察瑞舒伐他汀对血脂正常老年单纯收缩期高血压(ISH)患者动脉弹性的影响。方法102例ISH患者,随机分为安慰剂组(60例)和瑞舒伐他汀治疗组(62例),在服用降压药物基础上分别加服安慰剂1片或瑞舒伐他汀20 mg,每晚睡前服用,疗程6个月。每2个月随访1次,测量血压,检测踝肱脉搏波传导速度(baP-WV)。结果在治疗4个月后,治疗组baPWV及收缩压(SBP)、脉压(PP)较对照组降低(P<0.05);经6个月治疗后,治疗组baPWV及SBP、PP较对照组明显降低(P<0.01)。结论瑞舒伐他汀对ISH患者具有降低baPWV,改善动脉弹性的作用,也有益于降低SBP、缩小PP。
Objective To observe the effect of rosuvastatin on arterial elasticity in elderly patients with isolated liposiphonism and isolated systolic hypertension (ISH). Methods One hundred and two patients with ISH were randomly divided into placebo group (60 cases) and rosuvastatin group (62 cases). On the basis of taking antihypertensive drugs, placebo 1 or rosuvastatin 20 mg, Take at night before going to bed, treatment for 6 months. The patients were followed up once every two months, blood pressure was measured, and ankle brachial pulse wave velocity (baP-WV) was measured. Results After 4 months of treatment, the baPWV, SBP and PP in the treatment group were lower than those in the control group (P <0.05). After 6 months of treatment, the baPWV, SBP and PP in the treatment group were significantly lower than those in the control group Significantly lower (P <0.01). Conclusions Rosuvastatin has the effect of reducing baPWV and improving arterial elasticity in patients with ISH, and is also beneficial to reduce SBP and reduce PP.