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目的:研究糖尿病家族史对维吾尔族 2型糖尿病 (DM)患者胰岛素抵抗和β细胞功能的影响。 方法 :收集新疆和田地区有 DM家族史和无 DM家族史的糖尿病患者。按病程及有无家族史分为 4组 ,计算各组胰岛素抵抗指数 (HOMA- IR)、胰岛 β细胞功能指数 (HOMA- β)和胰岛素敏感指数 (ISI) ,并进行比较。 结果 :有糖尿病家族史的组 1和组 2的 ISI明显低于同病程没有家族史的组 3和组 4。 HOMA- IR明显高于同病程没有家族史的组3和组 4。结论:有糖尿病家族史的维吾尔族 2型糖尿病患者有更严重的胰岛素抵抗。
Objective: To study the influence of family history of diabetes on insulin resistance and β-cell function in Uygur type 2 diabetes mellitus (DM). Methods: We collected diabetics with DM family history and no DM family history in Hetian, Xinjiang. According to the course of disease and the presence or absence of family history, the patients were divided into 4 groups. HOMA-IR, HOMA-β and ISI were calculated and compared. Results: The ISI of group 1 and group 2 with a family history of diabetes were significantly lower than those of group 3 and group 4 with no family history of the same course. HOMA-IR was significantly higher than those in group 3 and group 4 with no family history of the same disease course. CONCLUSIONS: Uighur type 2 diabetics with a family history of diabetes have more severe insulin resistance.