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目的认识阴茎恶性黑色素瘤的生物学行为和临床病理特征。方法回顾分析1例阴茎恶性黑色素瘤病例,结合文献分析其发病情况、临床病理特征、诊断和治疗。结果患者行阴茎部分切除术,术后1年死于肺转移。免疫组化染色(S-P法):HMB45(+),S-100(+),Vimentin(+),Actin(SM)(-),Cytokeratin(-)。结论阴茎恶性黑色素瘤治疗主要采用手术切除,辅以放疗、化疗及免疫治疗,但预后差。
Objective To understand the biological behavior and clinicopathological features of penile malignant melanoma. Methods One case of penile malignant melanoma was retrospectively analyzed. The incidence, clinicopathological features, diagnosis and treatment of penile malignant melanoma were analyzed. Results The patient underwent partial resection of the penis and died of lung metastasis one year after operation. Immunohistochemical staining: HMB45 (+), S-100 (+), Vimentin (+), Actin (SM) (-) and Cytokeratin (-). Conclusions The treatment of penile malignant melanoma is mainly surgical resection, combined with radiotherapy, chemotherapy and immunotherapy, but the prognosis is poor.