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目的研究不同治疗方案对急性有机磷农药中毒(AOPP)致呼吸肌麻痹(RMP)的临床疗效。方法将我院2002年2月～2005年4月共收治的33例 AOPP 致 RMP 患者随机分为二组;A 组16例,给予突击量氯磷定为主的治疗方案;B 组17例,在 A 组治疗方案上全程联用足量纳洛酮,比较二组临床疗效。结果 A、B 二组的病人自主呼吸恢复时间(P<0.05)、呼吸机使用时间(P<0.01)、治愈率(P<0.05)均有显著性差异。结论救治 AOPP 致 RMP 患者,采用突击量氯磷定加纳洛酮治疗方案,有利于患者自主呼吸的恢复,缩短呼吸机使用时间,从而进一步提高临床治愈率。
Objective To study the clinical effects of different treatment regimens on respiratory muscle paralysis (RMP) caused by acute organophosphorus pesticide poisoning (AOPP). Methods A total of 33 AOPP-induced RMP patients who were treated in our hospital from February 2002 to April 2005 were randomly divided into two groups: group A (16 cases) A group of treatment programs in the full joint use of naloxone, the clinical efficacy of the two groups were compared. Results The recovery time of spontaneous breathing (P <0.05), the duration of ventilator (P <0.01) and the cure rate (P <0.05) of group A and group B were significantly different. Conclusion The treatment of AOPP-induced RMP in patients with the use of assault chlorpromazine plus naloxone treatment program is conducive to the recovery of patients with spontaneous breathing and shorten the use of ventilator time, thereby further improving the clinical cure rate.