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目的评价人参皂苷(GS)联合小剂量地塞米松(Dex)对原发性肝癌患者经动脉化疗栓塞术(TACE)后肝肾功能损害的防治效果。方法采用前瞻性随机对照研究方法,将120例原发性肝癌患者随机分为安慰剂组、Dex组、GS组、GS+Dex组,每组30例。参照世界卫生组织(WHO)抗肿瘤药物毒副反应分度标准,观察各组患者TACE术前第3天和术后第3、7天肝肾功能的变化。结果与安慰剂组比较,GS+Dex组对总胆红素、谷丙转氨酶/谷草转氨酶、尿素氮及Child-Pugh分级有明显减低作用,TACE术后第3天组间比较,差异均具有统计学意义(P均＜0．05)。GS和Dex单药对肝肾功能部分指标虽然也有一定保护作用,但从全面保护肝肾功能的角度看,其效果明显不如联合用药。结论GS联合小剂量Dex可有效防治原发性肝癌患者TACE术后的肝肾功能损伤。
Objective To evaluate the preventive and therapeutic effects of ginsenoside (GS) combined with low-dose dexamethasone (Dex) on liver and renal dysfunction after transcatheter arterial chemoembolization (TACE) in patients with primary liver cancer. Methods A prospective randomized controlled study was conducted in 120 patients with primary liver cancer who were randomly divided into placebo group, Dex group, GS group and GS + Dex group, 30 cases in each group. According to the World Health Organization (WHO) standard of antitumor drug toxicity and side effects, the changes of liver and kidney function were observed on the 3rd day before TACE and the 3rd and 7th day after TACE in each group. Results Compared with placebo group, total bilirubin, alanine aminotransferase / aspartate aminotransferase, urea nitrogen and Child-Pugh grade were significantly decreased in GS + Dex group. On the 3rd day after TACE, the differences were statistically significant Significance (P <0.05). GS and Dex monotherapy, although some indicators of liver and kidney function, but also a certain degree of protection, but from the perspective of comprehensive protection of liver and kidney function, the effect is obviously not as good as combination therapy. Conclusion GS combined with low-dose Dex can effectively prevent and treat hepatic and renal dysfunction after TACE in patients with primary liver cancer.