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目的:为评价改水降氟对地方性氟中毒的防治效果。方法:检测分析了(未改水)病区组、改水病区组、非病区组8～12岁儿童的尿氟和氟毒性效应指标。结果:尿氟均值病区组明显高于改水病区组(P<0.01)和非病区组(P<0.01);尿羟脯氨酸(HOP)排泄量均值病区组亦明显高于改水病区组(P<0.01)和非病区组(P<0.01)改水病区组8～12岁儿童氟斑牙患病率由10年前的82.4％降至6.45％,明显低于病区组(P<0.01)。斑釉齿指数呈依次递减趋势,病区组、改水病区组、非病区组分别为0.73、0.03、0.026。血清肌酸磷酸激酶(CPK)活性均值病区组非常明显地高于改水病区组(P<0.01)和非病区组(P<0.01)。上述各指标改水病区组与非病区组比较,均无显著性差异(P>0.05)。结论:改水降氟后,人群氟暴露水平下降,致使体内氟负荷减轻,氟毒性效应指标改善,起到了明显的防护作用。
Objective: To evaluate the prevention and cure effect of changing water and fluoride on endemic fluorosis. Methods: Urinary fluorosis and fluorosis toxicity indexes of 8 ~ 12 years old children in non-ward disease group, non-ward disease group and non-ward disease group were detected and analyzed. Results: Urinary fluoride mean value in the ward group was significantly higher than that in the water-wasting disease group (P <0.01) and non-ward group (P <0.01). The urinary hydroxyproline (HOP) The prevalence of dental fluorosis in children aged 8 ~ 12 years in the water-damaged area (P <0.01) and non-ward areas (P <0.01) decreased significantly from 82.4% to 6.45% 10 years ago, significantly lower In the ward group (P <0.01). Spot glaze tooth index showed a decreasing trend in turn, ward group, water-affected area group, non-ward group were 0.73,0.03,0.026. Serum creatine phosphokinase (CPK) activity in the ward was significantly higher than that in the watertown (P <0.01) and non-ward (P <0.01) groups. There was no significant difference between the above indexes in water-affected areas and non-ward areas (P> 0.05). CONCLUSION: After the water is changed into fluoride, the fluoride exposure in the population is decreased, which leads to the reduction of fluoride load in the body and the improvement of the index of fluoride toxicity, which plays a significant protective role.