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给15例内源性抑郁病人以治疗日剂量的1/3在治疗开始时一次投药,24小时后测定阿米替林及其代谢产物的血药浓度。此试验浓度与治疗剂量下的稳态浓度有良好的线性关系,说明试验浓度可用于预测稳态浓度,并可用于推算个体欲达到适宜浓度范围所需的阿米替林日剂量。
Fifteen patients with endogenous depression were dosed once daily at the beginning of treatment with a dose of one third of the daily dose of the treatment, and blood concentrations of amitriptyline and its metabolites determined 24 hours later. This test concentration has a good linear relationship with the steady-state concentration at the therapeutic dose, indicating that the test concentration can be used to predict the steady-state concentration and can be used to calculate the daily dose of amitriptyline for an individual to reach the appropriate concentration range.