胃癌患者血清3种肿瘤标志物测定的临床意义

• 作 者: 周睿哲 傅宝玉 王炳元 石田 陆建忠
• 机 构: 沈阳医学院附属中心医院内科,中国医科大学附属第一医院内科,沈阳矿务局总医院内科
• 出 处: 中国实用内科杂志
• 发表日期: 1997年12期
• 关键词: 胃癌患者血清 肿瘤标志物 癌相关抗原 血清测定 胃窦癌 诊断灵敏度 阳性似然比 胃癌诊断 沈阳医学院 酶免疫法

对３０例胃癌患者和３０例对照组患者血清测定癌胚抗原（ＣＥＡ）及癌相关抗原（ＣＡ１９－９，ＣＡ１２５）水平。结果表明胃癌组血清中ＣＥＡ，ＣＡ１９－９及ＣＡ１２５水平显著高于对照组（Ｐ＜０．０１）。胃癌组血清ＣＥＡ，ＣＡ１９－９，ＣＡ１２５的灵敏度分别是３６．６７％，４０．００％及３３．３３％。在三者联合检测中，以ＣＡ１９－９与ＣＥＡ联合检测最佳，其灵敏度可提高至６０％，阳性似然比为６．０。由此认为，肿瘤标志物的联合检测可提高胃癌的诊断灵敏度。

Serum carcinoembryonic antigen (CEA) and cancer-associated antigen (CA19-9, CA125) levels were measured in 30 patients with gastric cancer and 30 controls. The results showed that the serum levels of CEA, CA19-9 and CA125 in the gastric cancer group were significantly higher than those in the control group (P<0.01). The sensitivity of serum CEA, CA19-9 and CA125 in gastric cancer group was 36.67%, 40.00% and 33.33%, respectively. Among the three combined tests, the combined detection of CA19-9 and CEA was the best, the sensitivity was increased to 60%, and the positive likelihood ratio was 6.0. Therefore, the joint detection of tumor markers can improve the diagnostic sensitivity of gastric cancer.