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目的:探讨药物所致双硫仑样反应的临床特点及误诊原因。方法:回顾性分析初诊误诊的13例药源性双硫仑样反应患者的临床资料。结果:误诊为输液反应的3例,酒精中毒的3例,药物过敏的2例,急性冠脉综合征的1例,肺炎合并心力衰竭的1例,先兆流产的1例,感染性休克的1例,中暑的1例,误诊时间为1～12h,中位时间5h。对患者病史询问不详,对是否使用乙醇制品未予重视及医生对此病认识较少是主要的误诊原因。结论:提高对此病的认识,详细询问病史,是避免误诊的主要方法。
Objective: To investigate the clinical characteristics and misdiagnosis of drug-induced disulfiram-like reaction. Methods: The clinical data of 13 cases of drug-induced disulfiram-like reaction in newly diagnosed patients were retrospectively analyzed. Results: Misdiagnosed as infusion reaction in 3 cases, alcohol poisoning in 3 cases, drug allergy in 2 cases, acute coronary syndrome in 1 case, pneumonia complicated with heart failure in 1 case, threatened abortion in 1 case, septic shock in 1 case Cases, one case of heat stroke, misdiagnosis time is 1 ~ 12h, the median time 5h. Unknown history of the patient’s inquiry, the use of ethanol products are not taken seriously and the doctor is less aware of the disease is the main cause of misdiagnosis. Conclusion: To improve the understanding of the disease, detailed history, is to avoid the main method of misdiagnosis.