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在急性心肌梗塞(AMI)的动物模型中,葡萄糖-胰岛素-钾(GIK)静脉滴注能使缺血区收缩力增加,心前心电标测 ST 段抬高总和及范围下降,梗塞区肌酸激酶耗竭和坏死减少,以及心室颤动的发生率和易激性降低。前瞻性随机研究也显示,静脉滴注 GIK 对急性心肌梗塞患者是安全的,并能减少室性心律失常的发生率。然而尚缺乏用 GIK 治疗急性心肌梗塞患者可缩小梗塞范围的结论性资料。本文通过心肌梗塞急性期的核素心室造影和出院前康复期的造影剂心室造影,作随机的前瞻性研究,以期阐明 GIK 对急性心肌梗塞患者左室功能的影响。方法:急性心肌梗塞患者28例,均为起病后12
In animal models of acute myocardial infarction (AMI), intravenous infusion of glucose-insulin-potassium (GIK) resulted in an increase in contractile force in the ischemic area, an increase in the sum of ST-segment elevation in the ECG and a decrease in the range of infarct size A decrease in acid kinase depletion and necrosis, and a decrease in the incidence and irritability of ventricular fibrillation. Prospective randomized studies have also shown that intravenous infusion of GIK is safe for patients with acute myocardial infarction and reduces the incidence of ventricular arrhythmias. However, there is a lack of conclusive data on the extent to which infarction can be reduced in patients with acute myocardial infarction treated with GIK. In this paper, a randomized, prospective study of radionuclide ventriculography in acute myocardial infarction and convalescent contrast medium before discharge from hospital to clarify the effect of GIK on left ventricular function in patients with acute myocardial infarction. Methods: Acute myocardial infarction in 28 patients, both after onset 12