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本文采用地高辛放射免疫测定法检测42例慢性心功能不全患者和31例正常人血浆EDLF浓度,结果显示:慢性心功能不全组血浆EDLF浓度明显高于正常组,而各级心功能不全组之间血浆EDLF浓度无明显差别;右心功能不全组血浆EDLF高于左心功能不全;心功能不全患者血浆EDLF浓度与血清K~+呈明显负相关(r=-0.37,n=35,P<0.025),而与血清Na~+无明显相关。内源性洋地黄样因子Endogenous digitalis-like factor,EDLF)是体内具有洋地黄样作用的生物活性.物质,能抑制钠-钾ATP酶活性,竞争性抑制~3H哇巴因与受体结合,可与地高辛抗体发生交叉免疫反应,有强心、缩血管和利尿作用。为探讨EDLF与心功能不全的关系,我们对42例慢性心功能不全患者和31例正常人采用地高辛放射免疫测定法进行血浆EDLF浓度检测,以分析其意义。
In this paper, digoxin radioimmunoassay 42 cases of patients with chronic heart failure and 31 cases of normal plasma EDLF concentrations showed that: the concentration of plasma EDLF in patients with chronic heart failure was significantly higher than the normal group, and all levels of cardiac dysfunction group There was no significant difference in the plasma EDLF concentrations between the two groups. The plasma EDLF in patients with right ventricular dysfunction was higher than that in patients with left ventricular dysfunction. The plasma EDLF concentrations in patients with cardiac insufficiency were negatively correlated with serum K ~ + (r = -0.37, n = 35, P <0.025), but no significant correlation with serum Na ~ +. Endogenous digitalis-like factor (EDLF), an endogenous digitalis-like factor that inhibits sodium-potassium ATPase activity and inhibits ~ 3H ouabain binding to the receptor, is a digitalis-like bioactive substance in the body, Cross-immunization with digoxin antibodies, a cardiac, vasoconstrictor and diuretic effect. In order to explore the relationship between EDLF and cardiac insufficiency, 42 patients with chronic heart failure and 31 normal subjects were detected by digoxigenin radioimmunoassay for the determination of plasma EDLF concentration to analyze its significance.