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目的:比较玻璃化冷冻人卵裂期胚胎解冻后卵裂球损伤和继续发育对种植率以及临床妊娠率的影响。方法:选择在辅助生殖中心行181个卵裂期的FET周期进行研究。试验一根据复苏胚胎有无损伤和继续发育分为:A有损伤无发育,B无损伤有发育,C无损伤无发育,D有损伤有发育4组;试验二以B组无损伤有发育为基础,据移植继续发育胚胎数目分为:B1组1个胚胎继续发育,B2组2个胚胎继续发育,B3组3个胚胎继续发育,比较种植率以及临床妊娠率。结果:B组妊娠率、胚胎种植率高于A、C两组,差异有统计学意义(P<0.05);B3组妊娠率高于B1、B2两组,差异有统计学意义(P<0.05)。但胚胎种植率、多胎妊娠率各组间差异无统计学意义(P>0.05)。结论:解冻复苏胚胎继续培养后是否有进一步发育对预测临床妊娠较卵裂球是否损伤更有价值。
OBJECTIVE: To compare the effects of blastocyst damage and subsequent development on implantation rate and clinical pregnancy rate after thawing of vitrified human cleavage stage embryos. Methods: FET cycles of 181 cleavage stages in assisted reproductive centers were studied. A test embryos according to whether the damage and continue to develop divided into: A no injury development, B development without damage, C no damage no development, D have damage to develop 4 groups; Based on the number of embryos that continue to grow after transplantation, one embryo continues to develop in group B1, two embryos in group B2 continue to develop, and three embryos in group B3 continue to develop. The implantation rate and clinical pregnancy rate are compared. Results: The pregnancy rate and embryo implantation rate in group B were significantly higher than those in groups A and C (P <0.05). The pregnancy rate in group B3 was higher than that in group B1 and B2 (P <0.05) ). However, there was no significant difference in embryo implantation rate and multiple pregnancy rate (P> 0.05). Conclusion: It is more valuable to predict whether the clinical pregnancy is more damaging than the blastomere after thawed and resuscitated embryos continue to develop.