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目的:了解3 340例住院患儿血清25-羟维生素D[25-(OH)D]的基线水平和儿科常见疾病谱、不同年龄段、不同性别及季节的25-(OH)D水平,并分析其与临床指标之间的相关性。方法:随机选取3 340例住院患儿,ELISA方法检测血清25-(OH)D的水平,并用Pearson相关分析探讨25-(OH)D水平与患儿临床指标如肝功能、心肌酶谱、免疫球蛋白、T淋巴细胞亚型、甲状腺功能的相关性。结果:3 340例患儿中男1 850例,女1 490例,平均血清25-(OH)D水平为(33.00±13.42)ng.m~(-1)。新生儿疾病患儿血清25-(OH)D水平最低,其次是原发性肾病综合征、过敏性紫癜及幼年类风湿性关节炎患儿。足月儿较早产儿血清25-(OH)D水平高。除新生儿外,随年龄增加,患儿血清25-(OH)D水平逐渐降低,不足百分比逐渐增加。不同年龄组男性、女性25-(OH)D水平无显著差异。住院患儿夏季25-(OH)D水平最高。25-(OH)D与体质指数(BMI)、ALT、AST、磷酸肌酸激酶(CK)、磷酸肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)、游离T_4(FT_4)、游离T_3(FT_3)呈正相关,与AKP、免疫球蛋白E(Ig E)、免疫球蛋白M(Ig M)呈负相关。结论:住院患儿维生素D不足发生率较高,不同疾病其不足程度不同,血清25-(OH)D水平与BMI、过敏、心肌受损、甲状腺功能可能有一定的相关性。
OBJECTIVE: To understand the baseline levels of 25-hydroxyvitamin D [25- (OH) D] and the spectrum of common pediatric diseases, age-related, gender and seasonal 25- (OH) D levels in 3 340 hospitalized children and Analysis of its correlation with clinical indicators. Methods: A total of 3 340 hospitalized children were randomly selected. Serum 25- (OH) D levels were measured by ELISA. Pearson correlation analysis was used to investigate the relationship between 25- (OH) D levels and clinical parameters such as liver function, myocardial enzymes, Globulin, T lymphocyte subsets, thyroid function. Results: There were 1,350 males and 1,390 females out of 3 340 children with a mean serum 25- (OH) D level of (33.00 ± 13.42) ng.m -1. Serum 25- (OH) D levels were the lowest in neonates with neonatal disease, followed by those with primary nephrotic syndrome, Henoch-Schonlein purpura and juvenile rheumatoid arthritis. Full-term children with preterm serum 25- (OH) D levels. In addition to newborns, with age, children with serum 25- (OH) D levels gradually decreased, less than the percentage increased. There was no significant difference in 25- (OH) D levels between men and women in different age groups. Inpatients had the highest level of 25- (OH) D in summer. 25- (OH) D and body mass index (BMI), ALT, AST, creatine kinase CK, CK- MB, LDH and FT 4 ), Free T_3 (FT_3), and negatively correlated with AKP, Ig E and IgM. Conclusions: The incidence of vitamin D deficiency in hospitalized children is higher than that in other diseases. The level of serum 25- (OH) D may be related to BMI, allergy, myocardial damage and thyroid function.