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目的：探讨胃粘膜对重复应激性刺激产生的耐受性。方法：采用重复浸水束缚应激（ＷＲＳ）制作动物模型，大体及光镜下动态观察粘膜损伤程度及组织学的变化。结果：单次应激后胃粘膜出现广泛的点、线状出血性坏死灶，粘膜明显充血水肿。镜下见出血性坏死灶呈火山口状，几乎达粘膜肌层，粘膜下层充血水肿；重复应激后，出血性坏死灶明显减少、变浅，粘膜下层充血水肿减轻，同时粘膜细胞呈现出活跃的增殖状态。结论：单次应激可引起严重的胃粘膜损伤，但重复应激可使胃粘膜产生耐受性；细胞增殖在这一现象中有重要作用。
Objective: To investigate the tolerance of gastric mucosa to repetitive stress stimuli. Methods: Animal model was established by repeated immersion restraint stress (WRS). The changes of mucosal injury and histology were observed under light microscope and grossly. Results: A single gastric mucosa after a wide range of points, linear hemorrhagic necrosis, mucosal congestion and edema. Microscopic hemorrhagic necrotic lesions were crater-like, almost up to the muscularis mucosa, submucosal congestion and edema; repetitive stress, hemorrhagic necrosis significantly reduced, shallow, submucosal congestion and edema reduced, while mucosal cells showed an active Proliferation status. Conclusion: Single stress can cause serious gastric mucosal injury, but repeated stress can cause gastric mucosal tolerance; cell proliferation plays an important role in this phenomenon.