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“药物假日”和帕金森氏病使用L_多巴或L_多巴与长别多巴合用治疗帕金森氏病(PD)是过去十年中神经病学治疗学中的一个重要进展.但是,长期L_多巴疗法的疗效可随治疗时间的延长而逐渐减退,且该药引起的副作用的发生率也逐渐增加,如服药5年后有40-80%的病人发生多动症,此外,尚有:“开—关”现象、中毒性精神症状、肌阵挛、肌张力障碍及运动技能改变等副作用.减少剂量虽可使副作用改善,但若减量过
“Drug Holiday” and Parkinson’s Disease The combination of L-dopa or L-dopa with chilbide’s treatment of Parkinson’s disease (PD) is an important advance in neurological therapeutics over the past decade. However, the efficacy of long-term L-dopa therapy can be gradually reduced with the prolongation of treatment time, and the incidence of side effects caused by the drug also gradually increased, such as taking drugs 5 to 40% of patients with ADHD, in addition, There are: “On-off” phenomenon, toxic psychiatric symptoms, myoclonus, dystonia and motor skills to change the side effects.Although reducing the dose can improve the side effects, but if the reduction