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目的探讨心率变异性与高血压病动脉硬化和早期肾损害的相关性。方法对健康体检中筛选已确诊原发性高血压病164例,进行心率变异性(HRV-SDNN)、尿微量白蛋白和臂踝脉搏波传导速度(ba PWV)以及血压、BMI和血生化检查检测,并与200例健康受试者(正常对照组)进行对比分析。结果 (1)两组在脉压差、体重指数(BMI)、低密度胆固醇(LDL)、甘油三酯(TG)、高密度脂蛋白(HDL)、血糖、血尿酸、尿微量白蛋白、ba PWV和SDNN方面的比较,差异有统计学意义(均P<0.05)。(2)SDNN与ba PWV两者具有明显相关性(r=-0.72,P<0.01)。(3)SDNN与尿微量白蛋白两者具有显著相关性(r=-0.81,P<0.01)。结论心率变异性降低是高血压病动脉粥样硬化和早期肾功能损害的危险因素。通过心率变异性的分析,对评估和预测血管病变和靶器官损害均有重要的指导意义。
Objective To investigate the relationship between heart rate variability and atherosclerosis and early renal damage in hypertensive patients. Methods A total of 164 patients with confirmed essential hypertension were screened for HRV-SDNN, ba-PWV and BP, BMI and blood biochemical tests Test, and with 200 healthy subjects (normal control group) for comparative analysis. Results (1) The changes of blood pressure, body mass index (BMI), low density cholesterol (LDL), triglyceride (TG), high density lipoprotein (HDL), blood glucose, serum uric acid, urine microalbumin, ba PWV and SDNN, the differences were statistically significant (P <0.05). (2) There was a significant correlation between SDNN and ba PWV (r = -0.72, P <0.01). (3) There was a significant correlation between SDNN and urinary albumin (r = -0.81, P <0.01). Conclusions Decreased heart rate variability is a risk factor for atherosclerosis and early renal impairment in hypertension. Through the analysis of heart rate variability, it has an important guiding significance for the assessment and prediction of vascular lesions and target organ damage.