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曾有报道IgG 静脉治疗因膜性肾炎或狼疮性肾炎所致的肾病综合征有效。除了其间接的免疫调节机制外,IgG 可能有直接溶解免疫沉淀物的作用。为了对这些初步的观察进行评价,对6例罹患肾小球肾炎的病人进行了大剂量IgG 静脉治疗观察。治疗用IgG(sandoglobulin)每天0.4g/kg,输注时间应在10小时以上,五天为一疗程。1～2月后再重复上述治疗。IgG 治疗期间及治疗后应分别测量病人的蛋白尿、尿沉淀物、肾功能、血浆蛋白、脂类以及各种免疫复合物。结果发现:所有病人的血浆肌酐于IgG静脉治疗后都呈一过性不同程度地升高。这种升高通常不伴有其他任何症状,血浆尿素氮水平无明显地增高,血浆白蛋白有所增加,但白蛋白没有变化,即使肌酐浓度最高
It has been reported IgG intravenous therapy due to membranous nephritis or lupus nephritis caused by nephrotic syndrome effective. In addition to its indirect immunomodulatory mechanisms, IgG may have the effect of directly lysing immunoprecipitates. In order to evaluate these preliminary observations, 6 patients with glomerulonephritis were treated with high-dose IgG intravenous therapy. Treatment of IgG (sandoglobulin) 0.4g / kg per day, infusion time should be more than 10 hours, five days for a course of treatment. 1 to 2 months after the above treatment. Patients should be tested for proteinuria, urine sediment, renal function, plasma proteins, lipids, and various immune complexes during and after IgG treatment. The results showed that: All patients with plasma creatinine after IgG intravenous therapy showed a transient increased to varying degrees. This increase is usually not accompanied by any other symptoms, plasma urea nitrogen levels did not significantly increased, plasma albumin increased, but no change in albumin, even if the highest creatinine concentration