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In order to discover novel compounds with high-activity to control aphid,a series of novel(E)-β-farnesene analogues containing 1,2,3-thiadiazole were designed and synthesized,and their structures were confirmed by IR,~1H NMR,~(13)C NMR,and HRMS(ESI).The stability of representative compounds was studied by HPLC and ~1H NMR techniques.Repellent activity results indicated that compounds 8h and 8j displayed 60.3%and 62.0%repellent rates,respectively.The aphicidal bioassay results showed that most analogues exhibited considerable aphicidal activity against Myzus persicae.Especially,analogues 81,8s and 8t exhibited high activity with LC_(50) values of 33.4 μg/mL,50.2 μg/mL and 61.8 μg/mL,respectively,which were higher than the lead compound(E)-β-farnesene,but lower than commercial insecticide pymetrozine with a LC_(50) of 7.1 μg/mL
In order to discover novel compounds with high-activity to control aphid, a series of novel (E) -β-farnesene analogues containing 1,2,3-thiadiazole were designed and synthesized, and their structures were confirmed by IR, ~ 1H NMR , ~ (13) C NMR, and HRMS (ESI). The stability of representative compounds was studied by HPLC and ~ 1H NMR techniques. Repellent activity results indicated that compounds 8h and 8j displayed 60.3% and 62.0% repellent rates, respectively. aphicidal bioassay results showed that most analogues exhibited significant aphicidal activity against Myzus persicae. Especially, analogues 81, 8s and 8t exhibited high activity with LC_ (50) values of 33.4 μg / mL, 50.2 μg / mL and 61.8 μg / mL, respectively, which were higher than the lead compound (E) -β-farnesene, but lower than commercial insecticide pymetrozine with a LC 50 (50) of 7.1 μg / mL