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重组腺病毒载体因在体内能高效感染广泛的细胞类型而成为目前invivo基因治疗的一个颇具吸引力和极有前途的载体，但机体对腺病毒载体产生的抗原特异性细胞免疫和体液免疫反应使腺病毒介导的外源基因仅能短暂表达，且腺病毒载体重复基因转移时外源基因无法表达，由此大大降低了腺病毒载体基因治疗的效果。本文综述了机体对腺病毒的免疫反应，阐明了对抗体免疫反应进行调节和修饰可能从根本上提高腺病毒基因治疗的效果。
Recombinant adenovirus vectors are an attractive and promising vector for invivo gene therapy due to their ability to efficiently infect a wide range of cell types in vivo, but the antigen-specific cellular and humoral immune responses produced by the body to adenoviral vectors The adenovirus-mediated exogenous gene can only be transiently expressed, and the exogenous gene can not be expressed when the adenoviral vector repeats the gene transfer, thereby greatly reducing the effect of the adenovirus vector gene therapy. This article reviews the body’s immune response to adenovirus and clarifies that the modulation and modification of the immune response of the antibody may radically improve the effect of adenovirus gene therapy.